Tuesday, March 29, 2016

Vaccines and Autism

From https://www.facebook.com/aravindgandhi/posts/1430724080272218
Looks like MR (Measles Rubella) vaccination coverage in Tamil Nadu is taking a hit because of the anti-vaxxers and Ill-founded, exaggerated propagation of the side effects of Vaccines. I got a couple of calls whether to vaccinate or not, from family. In this regard, I will try to allay the doubts, FAQs and rumors regarding Vaccines, which the anti-vaccine lobby is spreading in Tamil Nadu (TN)
1.Are Vaccines 100% protective?
No drug can offer 100% cure rate for all persons. Vaccines too have a protective range (Effectiveness), ranging from 85% upto 99%, implying the percentage of population protected among vaccinated, depending on the disease.
2.If Vaccines don't provide 100% protection to the vaccinated people, then how do you claim it eliminate diseases?
This is where the concept of 'Herd Immunity' comes into play. A group or community or particular geographical area cannot be vaccinated 100%,because of various reasons other than anti-vaxxers, like certain people are contraindicated or may be in the age group not fit for that vaccine. And it is also not necessary to have 100% coverage, because 'Herd Immunity' can prevent the spread of infections, by reducing the number of susceptible persons for its transmission chain to happen. Hence this protects the non-vaccinated individuals too. Herd immunity target varies from 85-95% based on the disease. The anti-vaxxers in our state who claim that their children are not vaccinated, but didn't contract any disease are the ones who are actually enjoying that because of this unique 'Herd Immunity' effect in vaccines.
3.So even if I don't vaccinate my child, other vaccinated children will protect my child?
No. Even for herd immunity to be achieved, 85-95% coverage must be there. Tamil Nadu's current vaccine coverage is only 87%. Also, if there is an outbreak or the disease is brought by some person from outside our place, the vaccinated children have the least chance <1% to develop the disease, whereas, the non-vaccinated children have 99% chance of developing the disease.
4.Are Vaccines 100% safe?
Technically, vaccines are 99.999% safe. This 0.001% is attributed to moderate, but temporary discomforts.
5.Are there side effects/adverse reactions with vaccinations?
No drug is without side effects. But vaccine associated side effects are very mild. Serious adverse reactions are rarest of rare (1 in 1 million cases), that we cannot even 100% associate with vaccine. We have to do cost-benefit analysis. Vaccines are million times preferred.
6.What are the side effects of Measles Rubella vaccines?
Fever, Rashes, temporary Stiffness of joints are the most common but mild reactions
Twitches in muscles if fainted, Temporary low platelet count are moderate but rare reactions
Severe reactions like anaphylaxis are rarest.
7.Why are they giving MR vaccines only in TN? Are they using our children as lab rats to test these vaccines?
Most evil rumor. MR vaccine is already being given by many developed countries like Japan, USA etc for decades. Now, India wants to bring it in our country. We should be happy about this development. Any project or programme, before implemented country wide, a piloting will be done in few states or districts, to study the feasibility and practical difficulties that arise, so that it can be rectified before implementing nation wide. In that aspect, this 1st phase of MR vaccine campaign is conducted in selected places. And No, this phase is not only conducted in TN, but also in 4 other states- Karnataka, Pudhucherry, Goa and Lakshwadeep
8. Why do they show some students fainting or vomiting after MR vaccinations now?
Simple- Nervousness. MR vaccine is an Injection. Children are usually anxious and nervous about injections and these days anti-vaccine propaganda has made even the parents and older children more nervous. Fainting after a pain stimulus (Injection) or stress (To vaccinate or not to vaccinate) is very common and not to worry about. 10-15 minutes of rest under medical supervision is enough, at the most. Vasovagal effect.
9. Do we have a mechanism to report and investigate the adverse effects, if happens, after vaccination?
Yes. Govt of India has a very good surveillance system- AEFI
10. Is MR vaccine associated with autism?
No, not even remotely. All the claims were proved false by many studies. Autism has no link with MR vaccine or thiomersal.
11. Do doctors vaccinate their family members?
Yes, We do. I advise all my cousins and friends to get their child vaccinated.
12. Then why do some people oppose it?
Fools and Idiots want attention. MMR vaccine is being given in private for cost since long time in TN. Now, govt wants to give it for free to poor and public. If at all, there is a conspiracy, then its a conspiracy against Poor people getting health benefits.
I hope my friends reading this, medicos and non-medicos, convey these clarifications among your friends, family and neighbors and thwart the anti-vaccine propaganda.
Further queries are welcome.
P.S: If someone can do a Tamil translation of the above, I would be grateful :)
Following Links have details about vaccines


Answers for most of these questions are here, pls check,



















1. There are rumours that Mariano Anto Bruno Mascarenhas the last one in just three weeks old. new MR vaccine has been manufactured by a foreign company
According to Health Department officials, the vaccine, 'MR-VAC', is manufactured by an Indian Company named Serum Institute of India Pvt Ltd., and not by any foreign pharmaceutical company.

and will have side-effects. What's your view?
In Japan, the MMR vaccination has been discontinued, with single vaccines being used for each disease. However, rates of autism diagnosis have continued to increase, showing no correlation with the change. http://onlinelibrary.wiley.com/doi/10.1111/j.1469-7610.2005.01425.x/full

Conclusions:  The significance of this finding is that MMR vaccination is most unlikely to be a main cause of ASD, that it cannot explain the rise over time in the incidence of ASD, and that withdrawal of MMR in countries where it is still being used cannot be expected to lead to a reduction in the incidence of ASD.

All chemicals have effects as well as side effects
Sodium Chloride ie Common Salt can produce Hypernatremia https://en.wikipedia.org/wiki/Hypernatremia
Glucose can produce Diabetic Ketoacidosis https://en.wikipedia.org/wiki/Diabetic_ketoacidosis
Water can produce Volume Overload https://en.wikipedia.org/wiki/Volume_overload
Oxygen has side effects like Retrolental Fibroplasia https://en.wikipedia.org/wiki/Retinopathy_of_prematurity

It is incorrect to suggest someone to stop breathing since Oxygen has a side effect
Same Way
Looking at the side effects alone and not looking at the benefits is a wrong approach

There will be side effects
But the benefits are huge

We need to look at the very huge benefits and very miniscule side effects to decide whether the vaccine is needed or not

2. The MMR vaccine is given to many children who're registered with their pediatrician. Will they also need the new MR vaccine?
There are many different approaches in Vaccination
One is Pulse Coverage in which every one is given the vaccine irrespective of whether he/she has got it before or not. Pulse Polio is a good example for this
The Other Approach is to give only to those who have not got it
The Director of Public Health comes up with the Policy based on their assessment of the situation

3. Many parents believe that vaccination is a choice they should make. The govt saying this vaccine is compulsory has made them panic. What do you feel?
Vaccination must be compulsory.
Because an unvaccinated kid is a menance to the society, parents should not be allowed to make a choice.
It is like Speed Limit
Just because you have bought a car, you cannot drive it at 200 km per hour inside Chennai or drive after consuming alcohol
Please see the writeup in https://goo.gl/photos/sW9mRZ2Qi4yy5vB4A for more info

Rubella can cause Congenital Rubella Syndrome, where the child will be blind, deaf and have a problem in heart.

Measles can cause https://en.wikipedia.org/wiki/Subacute_sclerosing_panencephalitis and the child's brain would be affected

If any one wants to decide whether MR Vaccines are needed or not, he should visit the homes of children with SSPE or Congenital Rubella Syndrome and see the sufferings of the parents himself / herself

FB : 20 hrs

சுகாதாரம் சார்ந்து அமெரிக்காவில் நிறைய விழிப்புணர்வு இருப்பதாக நம்பப்படுகிறது. சில கேள்விகளுக்குத் தெளிவான பதில் இல்லாமல் குழம்பியிருக்கிறேன். மருத்துவர்கள் உடனே மருத்துவம் என்கிற அறிவியல் புனிதத்தை எப்படி கேள்வி கேட்கலாம் என்று ஓடி வந்து நையப் புடைப்பார்கள். நம்மூரில் போலியோ முற்றிலும் ஒழிக்கப்படக் காரணமாக இருந்த்தது தடுப்பூசிகள் என்பதில் மாற்றுக் கருத்தே இல்லை. அதே போல சில நோய்த் தடுப்புக்களில் முக்கியப் பங்காற்றியுள்ளதை மறுக்கவே முடியாது.

அமெரிக்காவில் ஒரு பெண் கர்ப்பமடைந்த காலத்திற்கு முழுவதும் நோய்த் தடுப்பு மருந்துகள் வழங்கப்படுகிறது. இதன் பக்க விளைவாக பிறக்கும் குழந்தைகளில் ஆட்டிசம் அதிகரித்துள்ளதாக மருத்துவர்கள் சிலரே கொடி பிடிக்கிறார்கள்.
The MMR vaccine controversy started with the 1998 publication of a fraudulent research paper in the medical journal The Lancet that lent support to the later discredited claim that colitis and autism spectrum disorders are linked to the combined measles, mumps and rubella (MMR) vaccine.[1] The media have been criticized for their naïve reporting and for lending undue credibility to the architect of the fraud, Andrew Wakefield.

Investigations by Sunday Times journalist Brian Deer reported that Andrew Wakefield, the author of the original research paper, had multiple undeclared conflicts of interest,[2][3] had manipulated evidence,[4] and had broken other ethical codes. The Lancet paper was partially retracted in 2004, and fully retracted in 2010, when The Lancet's editor-in-chief Richard Horton described it as "utterly false" and said that the journal had been "deceived."[5] Wakefield was found guilty by the General Medical Council of serious professional misconduct in May 2010 and was struck off the Medical Register, meaning he could no longer practice as a doctor in the UK.[6] In 2011, Deer provided further information on Wakefield's improper research practices to the British medical journal, BMJ, which in a signed editorial described the original paper as fraudulent.[7][8] The scientific consensus is the MMR vaccine has no link to the development of autism, and that this vaccine's benefits greatly outweigh its risks.

Following the initial claims in 1998, multiple large epidemiological studies were undertaken. Reviews of the evidence by the Centers for Disease Control and Prevention,[9] the American Academy of Pediatrics, the Institute of Medicine of the US National Academy of Sciences,[10] the UK National Health Service,[11] and the Cochrane Library[12] all found no link between the MMR vaccine and autism. While the Cochrane review expressed a need for improved design and reporting of safety outcomes in MMR vaccine studies, it concluded that the evidence of the safety and effectiveness of MMR in the prevention of diseases that still carry a heavy burden of morbidity and mortality justifies its global use, and that the lack of confidence in the vaccine has damaged public health.[12] A special court convened in the United States to review claims under the National Vaccine Injury Compensation Program rejected compensation claims from parents of autistic children.[13][14]

தடுப்பு மருந்துகள் நமக்குக் அளித்த வரப்பிரசாதம் ஒரு அளவிற்கு மேல் எதிர் விளைவுகளைக் கொடுத்துவிட்டதா?
Not at all

ஐரோப்பாவிலும் தடுப்பூசிகளின் எதிர்த் தரப்பு வலுத்துவருகிறது.
Fools oppose vaccines

என்னுடைய இரண்டாவது மகன் வயிற்றில் இருந்த போது குழந்தையின் மூளை வளர்ச்சிக்கு என்று நிறைய மருந்துகள் கொடுத்தார் மருத்துவர். குழந்தை clever ஆ பிறக்கும் என்று சொல்லிக் கொண்டே இருந்தார் மருத்துவர். அவர் clever என்று சொல்லும் வார்த்தை பழமையானது என்றே எடுத்துக் கொண்டேன். கணிதத் திறனோ அல்லது பரிட்சையில் நல்ல மதிப்பெண் எடுக்க வேண்டும் என்பதையோ சொல்கிறார். என்னுடைய இரண்டாவது மகன் ஒன்றும் பாதிப்படையவில்லை.
அமெரிக்காவில் ஒவ்வொரு மருத்துவ ஆலோசனையையும் ஒரு medical program ஆக்குவார்கள். அப்படி முக்கியமான நிகழ்வு இந்தப் பிள்ளைப் பேறு காலமும் கூட. இப்போது நம்மூரிலும் இந்த நாடகங்கள் அரங்கேறுகின்றன. அது கிடக்கட்டும். இன்றைய அமெரிக்காவில் நூறில் ஒரு குழந்தை ஆட்டிசம் பாதிப்பிற்கு ஆளாகியுள்ளது. ஒபாமா நிர்வாகத்தால் பெரும் பட்ஜெட் ஒதுக்கப்பட்டுள்ளது. சிறப்புப் பள்ளிகள் இல்லாத நகரங்களே கிடையாது என்கிறார்கள். மருத்துவம் செய்வது சாத்தியமில்லை. நூறில் இரண்டு என்பது விரைவில் வரும் என்கிறார்கள். என்ன நடக்கிறது என்று தெரியவில்லை. நமக்கு பாடம் எடுக்காமல், எளிதில் இதில் இருந்து விடுபடுவது எப்படி என்று யாரும் சொல்லமாட்டார்கள். ஆட்டிசம் நிச்சயமாக மரபு ரீதியாக வருவதில்லை. அப்படியானால் எங்கிருந்து?
It comes with increased detection and awareness
So Simple
That's all


தமிழ் இளவல் நவீன் The doctor(mbbs,dch) who is taking care of my child"s vaccine told me to avoid all non compulsory vaccines,and this will automatically make any parent to doubt abt the vaccines!
LikeReply2 mins
Mariano Anto Bruno Mascarenhas //
தமிழ் இளவல் நவீன் The doctor(mbbs,dch) who is taking care of my child"s vaccine told me to avoid all non compulsory vaccines,and this will automatically make any parent to doubt abt the vaccines!//

I made a simple request

Before posting anything
Please read once

You are asking questions which have been already answered

That is utter waste of time

If you are not ready to read what We have said
What is the point in calling for discussion
LikeReplyJust now
தமிழ் இளவல் நவீன் Of course i will! Just shared my experience.
LikeReply1 min
Mariano Anto Bruno Mascarenhas YES

Probably your kid has some congenital or acquired immunodeficiency

you please follow what your pediatrician said
LikeReplyJust now
Mariano Anto Bruno Mascarenhas //தமிழ் இளவல் நவீன் The doctor(mbbs,dch) who is taking care of my child"s vaccine told me to avoid all non compulsory vaccines,and this will automatically make any parent to doubt abt the vaccines!//

The question is simple
Did he ask to avoid THIS vaccine

If your pediatrician has asked you not to give, then probably your child has some immune deficiency. So Follow your doctor's advice

Very simple

Just because your pediatrician has asked not to give vaccines to your child

Why should all parents of kids with normal immune system get doubt

You alone are confused boss

you are extrapolating that
LikeReply1 min

Mariano Anto Bruno Mascarenhas Point is

This question has been already answered in the links I have shared above

Instead of asking questions which have been already answered, Why don't you just read once

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